Barcelona manager Hansi Flick announced a changed starting lineup for the trip to Rams Park Arena, with Dani Olmo selected as a false nine.
Olmo moves from a No. 10 role into the central attacking position, replacing Gabriel Jesus who drops to the bench.
Anthony Gordon and Lamine Yamal keep their places on the wings, while Fermin Lopez fills the hole left by Olmo's positional switch.
Pedri returns to the XI in place of Gavi, and summer signing Rodri retains his midfield position as Flick looks to control possession.
Pau Cubarsi and Joao Cancelo come into the defence, replacing Jules Kounde and Xavi Espart respectively, with Eric Garcia shifting to right back.
Gerard Martin continues as the second central defender and Joan Garcia remains in goal for the European fixture.
Raphinha Absence And Its Implications
Barcelona will be without Raphinha after the winger sustained a muscle injury in the back of his right thigh while playing for Brazil against Australia.
He was substituted at half time in that friendly and returned to Barcelona for medical examinations whose initial findings did not show a major tear.
Flick said the imaging showed something but it was not a big injury, and he warned the club must take care because Raphinha suffered three muscle injuries last season, according to The Athletic.
The absence forced Barcelona to keep Raphinha out of the recent league match with Getafe and the trip to Rams Park Arena as part of the same recovery period.
Flick will still rely on attacking options including Gabriel Jesus, Lamine Yamal and Anthony Gordon to provide width and pressing in Raphinha's absence.
Club president Joan Laporta reportedly offered encouragement about the winger's progress, saying the doctors expected him to be available for the Paris Saint-Germain match, though the club has not confirmed a return date.
